Gangliocytic paraganglioma associated with duodenal adenocarcinoma. Case report with immunohistochemical evaluation
Anders, K.H.; Glasgow, B.J.; Lewin, K.J.
Archives of Pathology and Laboratory Medicine 111(1): 49-52
1987
ISSN/ISBN: 0003-9985 PMID: 3800604 Document Number: 301251
We present the first reported case (to our knowledge) of duodenal gangliocytic paraganglioma (GPG) to be associated with an underlying invasive adenocarcinoma. The patient, a 71-year-old man, presented with epigastric tenderness and was found to have metastatic adenocarcinoma in two regional lymph nodes. Immunohistochemical evaluation of the GPG demonstrated positive staining for gastrin, glial-fibrillary acidic protein, glucagon, neuron-specific enolase, pancreatic polypeptide, S100 protein, somatostatin, and substance P. The clinical, pathologic, and immunohistochemical features of GPG are discussed, with a review of the literature.