The influence of Haloperidolum on white rat kidney after surgical removal of liver lobe
Zarebska, A.; Staszyc, J.
Zeitschrift für Mikroskopisch-Anatomische Forschung 101(2): 229-244
1987
ISSN/ISBN: 0044-3107 PMID: 3630334 Document Number: 301089
The influence of Haloperidolum on a white rat kidney was investigated. The liver lobe was removed in some rats. The drug was given by a stomach-tube in the dose of 8 mg/kg of body mass for 7 successive days. In the non-operated animals there were shown: degeneration of some kidney glomerules, increase of succinic and lactic dehydrogenase activities, increase of alkaline and acid phosphatase activities which may result from the increased activity of kidney tubules. Administration of Haloperidolum to the operated animals caused thickening of the basal laminae in a great number of kidney glomerules and tubules and also occurrence of the inflamed infiltrations around some glomerules. Local degeneration of the kidney cortex was observed in some animals. Nephrons seem to be capable of carrying out their function in this place. The decreased activity of the investigated enzymes may indicate the decrease of kidney metabolic efficiency after partial hepatectomy.