Creatine kinase BB and neuron specific r-enolase as biomarkers for lung cancer
Usui, A.; Fujita, K.; Imaizumi, M.; Abe, T.; Inoue, K.; Matsumoto, S.; Kato, K.
Gan no Rinsho. Japan Journal of Cancer Clinics 33(14): 1763-1770
1987
ISSN/ISBN: 0021-4949 PMID: 2826840 Document Number: 300175
The serum concentrations of both CK-BB and NSE in patients with various lung carcinoma have been determined by the enzyme immunoassay. Serum CK-BB levels were found to be significantly increased (less than 1.0 ng/ml) in patients with a small cell carcinoma (51 cases, 74.5%), adenocarcinoma (77 cases, 36.5%), and a squamous cell carcinoma (68 cases, 39.7%). The serum NSE levels also were increased (less than 6.0 ng/ml) in cases of small cell carcinoma (72.5%), adenocarcinoma (27.3%), and squamous cell carcinoma (26.5%). Since the serum concentrations of bos CK-BB and NSE changed in parallel with the clinical course, they may be useful biomarkers for monitoring the clinical course of patients with lung cancer, especially in cases of small cell carcinoma.