An Ultrastructural Study of Melanocytes and Mast Cells in the Depigmented Skin in Vitiligo
Osman, S.H.; Mehta, L.N.
Indian Journal of Dermatology Venereology and Leprology 53(2): 92-97
1987
ISSN/ISBN: 0378-6323 PMID: 28145309 Document Number: 300023
In the depigmented patch of ten vitiligo patients a few melanocytes were seen. Coagulation, fatty degeneration, focal aggregation of melanosomes and vacuolation were some of the changes seen in their cytoplasm. Many indeterminate cells were also observed. These resembled Langerhans cells morphologically but were without Birbeck granules. Basement membrane architect was lost. In the dermis mast cells and plasma like cells were seen. Collagenised nerves and blood vessels with reactive endothelial cells were the salient features.
Document emailed within 1 workday
Related Documents
van den Wijngaard, R.; Wankowicz-Kalinska, A.; Le Poole, C.; Tigges, B.; Westerhof, W.; Das, P. 2000: Local immune response in skin of generalized vitiligo patients. Destruction of melanocytes is associated with the prominent presence of CLA+ T cells at the perilesional site Laboratory Investigation; a Journal of Technical Methods and Pathology 80(8): 1299-1309Wershil, B.K.; Mekori, Y.A.; Murakami, T.; Galli, S.J. 1987: 125I-fibrin deposition in IgE-dependent immediate hypersensitivity reactions in mouse skin. Demonstration of the role of mast cells using genetically mast cell-deficient mice locally reconstituted with cultured mast cells Journal of Immunology 139(8): 2605-2614
Arizono, N.; Matsuda, S.; Hattori, T.; Kojima, Y.; Maeda, T.; Galli, S.J. 1990: Anatomical variation in mast cell nerve associations in the rat small intestine, heart, lung, and skin. Similarities of distances between neural processes and mast cells, eosinophils, or plasma cells in the jejunal lamina propria Laboratory Investigation; A Journal of Technical Methods and Pathology 62(5): 626-634
Dyduch, G.; Okoń, K.; Pescarini, E. 2011: Mast cells in melanocytic skin lesions. An immunohistochemical and quantitative study Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists 62(3): 139-144
Sharquie, K.E.; Noaimi, A.A.; Al-Mudaris, H.A. 2013: Melanocytes transplantation in patients with vitiligo using needling micrografting technique Journal of Drugs in Dermatology: Jdd 12(5): E74-E78
Zachariae, H.; Zachariae, C.; Deleuran, B.; Kristensen, P. 1993: Autotransplantation in vitiligo: treatment with epidermal grafts and cultured melanocytes Acta Dermato-Venereologica 73(1): 46-48
Lytinas, M.; Kempuraj, D.; Huang, M.; Kandere, K.; Boucher, W.; Letourneau, R.; Jeudy, S.; Fitzgerald, K.; Spear, K.; Athanasiou, A.; Theoharides, T.C. 2002: Azelastine's inhibition of histamine and tryptase release from human umbilical cord blood-derived cultured mast cells as well as rat skin mast cell-induced vascular permeability: comparison with olopatadine Allergy and Asthma Proceedings 23(1): 45-51
Olsson, M.J.; Juhlin, L. 1995: Clinical findings and therapeutic methods in vitiligo. Patient's own melanocytes produce new pigmentation Lakartidningen 92(13): 1341-1344
Sredni, B.; Friedman, M.M.; Bland, C.E.; Metcalfe, D.D. 1983: Ultrastructural, biochemical, and functional characteristics of histamine-containing cells cloned from mouse bone marrow: tentative identification as mucosal mast cells Journal of Immunology 131(2): 915-922
Nakano, T.; Kanakura, Y.; Asai, H.; Kitamura, Y. 1987: Changing processes from bone marrow-derived cultured mast cells to connective tissue-type mast cells in the peritoneal cavity of mast cell-deficient w/wv mice: association of proliferation arrest and differentiation Journal of Immunology 138(2): 544-549
Schmidt, U.; Leder, L.D. 1988: Ultrastructural findings in tissue mast cells in urticaria pigmentosa Zeitschrift für Hautkrankheiten 63(8): 651-657
Kvetnoĭ, I.M.; Iuzhakov, V.V. 1987: APUD and mast cells of the gastrointestinal system: immunohistochemical and ultrastructural identification Arkhiv Patologii 49(7): 77-80
Craig, S.S.; Schechter, N.M.; Schwartz, L.B. 1988: Ultrastructural analysis of human T and TC mast cells identified by immunoelectron microscopy Laboratory Investigation; a Journal of Technical Methods and Pathology 58(6): 682-691
Beitner, H.; Wennersten, G. 1983: The immediate action of long-wave ultraviolet radiation (UVA) on suprabasal melanocytes in human skin: a transmission electron microscopical study Acta Dermato-Venereologica 63(4): 328-334
Craig, S.S.; Irani, A.M.; Metcalfe, D.D.; Schwartz, L.B. 1993: Ultrastructural localization of heparin to human mast cells of the MCTC and MCT types by labeling with antithrombin III-gold Laboratory Investigation; A Journal of Technical Methods and Pathology 69(5): 552-561
Matsuda, H.; Ushio, H.; Paliwal, V.; Ptak, W.; Askenase, P.W. 1995: Adoptive cell transfer of contact sensitivity-initiation mediated by nonimmune cells sensitized with monoclonal IgE antibodies. Dependence on host skin mast cells Journal of Immunology 154(10): 5080-5092
Prunieras, M.; Moreno, G.; Dosso, Y.; Vinzens, F. 1976: Studies on guinea pig skin cell cultures. V. Co-culture of pigmented melanocytes and albino keratinocytes, a model for the study of pigment transfer Acta Dermato-Venereologica 56(1): 1-9
Dvorak, A.M.; Mihm, M.C.; Dvorak, H.F. 1976: Morphology of delayed-type hypersensitivity reactions in man. II. Ultrastructural alterations affecting the microvasculature and the tissue mast cells Laboratory Investigation; a Journal of Technical Methods and Pathology 34(2): 179-191
Yung, Y.P.; Moore, M.A. 1982: Long-term in vitro culture of murine mast cells. III. Discrimination of mast cells growth factor and granulocyte-CSF Journal of Immunology 129(3): 1256-1261
Brzeziński, P.M.; Godlewski, A. 2001: Topographical and quantitative post mortem assessment of the rat skin mast cells Folia Histochemica et Cytobiologica 39(2): 227-228