Chemotherapy of trypanosomiasis: the use of guanylhydrazone compounds in the treatment of experimental murine trypanosomiasis
Jennings, F.W.; Ulrich, P.; Cerami, A.
Tropical Medicine and Parasitology Official Organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft für Technische Zusammenarbeit 38(3): 181-186
1987
ISSN/ISBN: 0177-2392 PMID: 3124253 Document Number: 299978
The efficacy of 1,3,5-triacetylbenzene tris(guanylhydrazone) trihydrochloride (TBG) in the treatment of early and late stage infections of Trypanosoma brucei in mice was investigated. Successful treatment on day 3 pi could be achieved by doses of 2 x 2.5 mg/kg. When treatment was delayed to 21 days pi, however, a single dose of suramin (20 mg/kg) followed by TBG (3 days later) at 1 x 10 mg/kg twice daily for 4 days were required to cure all animals. High rates of cure were also obtained in mice given 1 x 20 mg/kg suramin and 4 x 15 gm/kg TBG, or difluoromethylornithine (DFMO) 2% solution in drinking water for 14 days followed by TBG at 4 x 15 mg/kg or 1 x 10 mg/kg twice daily for 4 days. Other guanylhydrazone derivatives were investigated for the treatment of chronic T. brucei infections, but failed to given any permanent cures at the limited dose levels used (