Fanweed toxicosis in cattle: case history, analytical method, suggested treatment, and fanweed detoxification
Smith, R.A.; Crowe, S.P.
Veterinary and Human Toxicology 29(2): 155-156
1987
ISSN/ISBN: 0145-6296 PMID: 3576950 Document Number: 299457
Two hundred and twenty head of pregnant cows were fed virtually 100% fanweed (Thlaspi arvense) in November 1984. One hundred became distressed and showed signs of colic within 4 hr of feeding. Eight died over the next 5 days despite removal of the feed and symptomatic treatment. PM examination revealed massive submucosal oedema of the wall of the forestomachs, particularly the rumen. Four abortions occurred. The feed was analyzed and was found to liberate 250 mg/100 g of allylisothiocyanate (AITC). Possible methods of treatment were devised in case the problem should recur. Fanweed contains sinigrin and the enzyme myrosin. When the plant is crushed and moistened, AITC is formed along with glucose and potassium acid sulfate. Application of the Le Chatelier's principle led to an investigation of the effect of pH on in vitro generation of AITC. Methods of destroying AITC were also examined, and detoxification studies were undertaken on fanweed.