Pathologic features of the femoral heads in a patient aged 14 1/2 years with spondyloepiphyseal dysplasia with osteoarthritis
Stanescu, R.; Stanescu, V.; Bordat, C.; Maroteaux, P.
Journal of Rheumatology 14(5): 1061-1067
1987
ISSN/ISBN: 0315-162X PMID: 3430512 Document Number: 298730
We describe a patient with spondyloepiphyseal dysplasia and precocious hip osteoarthritis. Bilateral hip arthroplasty was performed at the age of 14 1/2 years. Pathologic examination revealed severe osteoarthritic deformities: flattened and deformed femoral heads, were almost completely covered by abnormal cartilaginous, fibrocartilaginous and fibrous tissues showing intense degenerative and regenerative processes. The electron microscopic examination of chondrocytes showed large intracytoplasmic accumulations of glycogen and of microfilaments and many small vesicles suggesting intense micropinocytosis and/or microexocytosis.