End organ responsiveness to hCG in metoclopramide induced hyperprolactinaemia in immature rats
Lall, S.B.; Ghosh, M.
Indian Journal of Experimental Biology 25(7): 436-438
1987
ISSN/ISBN: 0019-5189 PMID: 3436641 Document Number: 298115
The effect of metoclopramide induced hyperprolactinaemia on the end organ responsiveness to hCG was investigated in immature male and female rats. The weight of end organs (ovaries, uterine horns, testis, prostate and seminal vesicles) and serum prolactin levels were measured in control, hCG, metoclopramide and metoclopramide + hCG treated groups. Metoclopramide produced significant increase in prolactin levels in immature animals. The hCG treatment resulted in marked increase in end organ weights and caused hyperprolactinaemia. Metoclopramide when administered alone and with hCG caused significant decrease in end organ weights as compared to control animals. However, serum prolactin levels remained high as compared to control group. The above results indicate that the reduced responsiveness of end organs to hCG during hyperprolactineamia is possibly due to its direct inhibitory effect at gonadal level.