The influence of ketanserin, droperidol and hydergine on postoperative hypertension during early recovery following major abdominal surgery
Anger, C.; Van Aken, H.; Hoch, D.; Lawin, P.
Acta Anaesthesiologica Belgica 38(2): 153-159
1987
ISSN/ISBN: 0001-5164 PMID: 3661107 Document Number: 296991
Forty adult patients, who developed postoperative hypertension (greater than 160/90 mm Hg) following major abdominal surgery were given double-blind, randomized either ketanserin 10 mg i.v. (n = 10), droperidol 5 mg i.v. (n = 10), hydergine 0.9 mg i.v. (n = 10) or placebo solution (n = 10). Following the injection of ketanserin or droperidol systolic and diastolic blood pressure decreased significantly (p less than 0.001 and p less than 0.01), but were no longer significantly lowered 30 minutes following the injection in 5 out of 10 ketanserin treated and in 8 out of ten droperidol treated patients. Neither hydergine nor placebo had a significant effect on blood pressure. It is concluded, that both ketanserin and droperidol have a moderate and short acting antihypertensive effect.