Congenital metacarpal fusion associated with polydactyly
Ogino, T.; Ohshio, I.
Handchirurgie Mikrochirurgie Plastische Chirurgie Organ der Deutschsprachigen Arbeitsgemeinschaft für Handchirurgie Organ der Deutschsprachigen Arbeitsgemeinschaft für Mikrochirurgie der Peripheren Nerven und Gefasse Organ der V. 19(5): 237-240
1987
ISSN/ISBN: 0722-1819 PMID: 3666589 Document Number: 296532
A case of congenital fusion of metacarpal bones with polydactyly is reported. The fusion occurred between the proximal parts of the third and the fourth metacarpal bones. The same type of anomaly was induced in rat fetuses by oral administration of myleran. The anomalies for which the critical period is the same as both metacarpal fusion and polydactyly, were analysed. From the results of the experimental study, the authors propose that the cause of the metacarpal fusion associated with polydactyly is the combination of a disorder of ectoderm-mesoderm interaction and a deficit of mesenchymal cells in the limb bud.