A case of breast carcinoma with lung metastasis
Okayasu, T.; Masuda, T.; Kawabata, M.; Imai, T.; Hashimoto, M.; Inoue, K.; Tanabe, T.
Gan no Rinsho. Japan Journal of Cancer Clinics 33(6): 720-722
1987
ISSN/ISBN: 0021-4949 PMID: 3599480 Document Number: 295526
A 37-year-old female, who had undergone a left standard mastectomy in May, 1983 for breast cancer, was treated with Tamoxifen and FT-207 postoperatively. The patient had no further evidence of disease until two and one-half years later, when a routine chest film showed a single, half-rounded density 6.5 cm in diameter in the hilus of her left lung. Bestrabucil, the benzoate of an estradiol-chlorambucil conjugate, was administered p.o. at a daily dose of 200 mg for four weeks. Thereafter, the tumor greatly decreased in size to 3.0 cm in diameter. When a left upper lobectomy was performed, the tumor was found to be necrotic tissue. Microscopically, a small cancer nest similar to the primary breast carcinoma was observed in the center of the necrosis. The necrotic tissue was surrounded with cellular infiltrate, markedly consisting of histiocytes.