Mean residence time for drugs subject to reversible metabolism
Aarons, L.
Journal of Pharmacy and Pharmacology 39(7): 565-567
1987
ISSN/ISBN: 0022-3573 PMID: 2886630 Document Number: 294856
Conventional methods based on moment analysis lead to biased estimates of the mean residence time for drugs subject to reversible metabolism. A stochastic approach is described which enables unbiased estimation of the mean residence time.
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