Clinical findings and prognosis in 1076 patients with ruptured intracranial saccular aneurysm. a prospective consecutive study
Rosenørn, J.; Eskesen, V.; Schmidt, K.; Espersen, J.O.; Haase, J.; Harmsen, A.; Hein, O.; Knudsen, V.; Midholm, S.; Marcussen, E.
Ugeskrift for Laeger 149(43): 2908-2911
1987
ISSN/ISBN: 0041-5782 PMID: 3433470 Document Number: 294831
During the five-year period, 1978-1983, 1,076 patients with ruptured intracranial sacculate aneurysms were admitted to the six Danish neurosurgical departments. The patients were followed-up with control examinations three months and two years after hospitalization or until death. The material consisted of 674 (63%) women and 402 (37%) men. The median age was 49 years. The locations of the aneurysms were as follows: internal carotid artery 285 (26%), anterior cerebral communicating artery 383 (36%), middle cerebral artery 291 (27%), basilar and vertebral arteries 83 (8%) and other sites 34 (3%). Operation was undertaken in 670 patients and the prognosis in these patients was significantly better than for the non-operated patients in clinically comparable groups. The daily risk for renewed haemorrhage varied from 0.2% to 2.1% in the first two weeks after the initial insult. Patients in whom renewed haemorrhage occurred had significantly poorer prognosis than patients in whom renewed haemorrhage did not occur. The results after two years for all 1,076 patietns were: normal mental status 27%, slight dementia 16%, severe dementia 10%, vegetative state 1% and 46% had died. The best prognosis was observed in paitents with aneurysms in the internal carotid artery.