Effects of topical flurbiprofen in planned-extracapsular cataract extraction by a double-blind method
Tsuchisaka, H.; Takase, M.; Tobari, I.; Miyake, K.; Eguchi, K.
Nippon Ganka Gakkai Zasshi 91(5): 570-578
1987
ISSN/ISBN: 0029-0203 PMID: 3661309 Document Number: 294759
Inhibitory effects of topical flurbiprofen (FP) on miotic response and postoperative inflammation in cataract surgery were studied in a double blind experiment. Eight-four eyes of planned-extracapsular cataract extraction were treated with 0.1% of 0.0025% flurbiprofen 3, 2, 1 hours and 30 minutes before operation and three times daily for one week after surgery. The miotic index (Dmax-D/Dmax-Dmin) was used as a parameter for evaluation of pupil size. Effects of FP were evaluated in 24 eyes treated with 0.1% FP and 28 eyes treated with 0.0025% FP. Intraoperative and postoperative pupal constriction was similar with 0.1% FP and 0.0025% FP except for the day following surgery. Significant differences were not found in corneal congestion, the cells and flare in the anterior chamber and the cells in the vitreous body. However, 0.1% FP was effective for intraoperative and postoperative miosis in the patients younger than 75 years old. Furthermore, postoperative inflammatory reactions were suppressed by 0.1% FP in patients with a miotic index lower than 30%. Seven cases of intraoperative complication were experienced in the 0.0025% FP group, but none in the 0.1% FP group. Postoperative complication were found in one case in each group. Topical FP of 0.1% was significantly useful to reduce intraoperative complications.