A nuclear deoxyribonucleic acid analysis of normal and abnormal vulvar epithelium
Evans, A.S.; Monaghan, J.M.; Anderson, M.C.
Obstetrics and Gynecology 69(5): 790-793
1987
ISSN/ISBN: 0029-7844 PMID: 2437504 Document Number: 294554
Vulvar and groin skin from 21 women with clinical squamous cell carcinoma of the vulva was compared with that from nine patients with vulvar intraepithelial neoplasia. Feulgen-stained nuclear densitometry showed a constancy of Feulgen-deoxyribonucleic acid (DNA) density in normal epithelium and all subepithelial connective tissue nuclei. At three sites--tumor edge, opposite labia, and perineum--there were significant differences in nuclear chromatin content between the two groups and also as compared with normal epithelium.