Dermatitis associated with the use of primidone in a dog
Henricks, P.M.
Journal of the American Veterinary Medical Association 191(2): 237-238
1987
ISSN/ISBN: 0003-1488 PMID: 2956226 Document Number: 294537
A 9-year-old female dog with progressive pruritic dermatitis was examined 9 months after primidone treatment for general seizures had been initiated. Alopecia, scaling, ulceration, pigmentation, and fissuring occurred over the dorsal trunk, head, perineum, caudal aspect of the thighs, hocks, elbows, and paws. Hydropic degeneration of epidermal basal cells, mononuclear lichenoid infiltrate in the superficial dermis, and marked parakeratotic hyperkeratosis were found on biopsy. Antinuclear antibody in the serum was not detected and specific patterns of immunoglobulin deposition in the epidermis or basement membrane zone were lacking. Primidone-induced dermatitis was the presumptive diagnosis. Gradual withdrawal of the primidone and administration of corticosteroids and antibiotics to relieve the pruritis and to eliminate the secondary pyoderma resolved the dermatitis; siezures did not recur.