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Delayed-type allergy against various insulin preparations including human semisynthetic insulin

Würzburger, M.I.; Prelević, G.M.; Despotović, N.; Vucković, S.; Brkić, S.D.; Bozović, M.; Nastić-Mirić, D.

Annals of Allergy 59(1): 44-47

1987

ISSN/ISBN: 0003-4738
PMID: 3300437
Document Number: 294224
The authors present a patient with delayed-type allergy against insulin preparations of different species including highly purified monocomponent insulin and human semisynthetic insulin. Positive results for cutaneous delayed-type hypersensitivity and for lymphocyte blastogenesis suggested a type IV immunopathogenic reaction. Intradermal tests performed with various components of insulin preparations revealed delayed-type allergy to insulins of different species (bovine, porcine and human) but not to any of the other components.

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