Effect of acid extraction on the osteogenic activity of bone tissue
Sumarokov, D.D.
Voprosy Meditsinskoi Khimii 33(1): 51-54
1987
ISSN/ISBN: 0042-8809 PMID: 3107216 Document Number: 294109
Rat bones demineralized in HCl and TCA exhibited distinct osteoinductive activity while the bones demineralized using EDTA did not show the activity. HCl- and TCA-extracts of bones differed from EDTA extracts by chromatographic and radiochromatographic profiles. At the same time, HCl- and TCA-extracts contained additional fraction. The substances involved in the fraction appear to be responsible for inhibition of the osteoinductive factor of bone tissue.
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