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Effects of concanavalin a on 67Ga binding by tumor cells

Anghileri, L.J.; Crone-Escanye, M.C.; Robert, J.

NUKLEARMEDIZIN. Nuclear Medicine 26(2): 105-107

1987

ISSN/ISBN: 0029-5566
PMID: 3473448
Document Number: 294074
The in vitro uptakes of 67Ga-citrate and 45Ca-chloride in the presence of concanavalin A have shown that at low concentrations (10-50 micrograms/ml) 67Ga presents a significant increase not observed for 45Ca. At higher concentrations there is a sharp augmentation of both 67Ga and 45Ca incorporations. The augmentation of Trypan blue inclusion is a concomitant phenomenon at any concanavalin A concentration that indicates tumor cell plasma membrane changes in direct relationship with 67Ga uptake increase.

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