Elimination of T lymphocytes from the bone marrow in HLA-incompatible bone marrow transplantation
Müller, A.; Zintl, F.
Folia Haematologica 114(3): 359-366
1987
ISSN/ISBN: 0323-4347 PMID: 2444509 Document Number: 292488
The method presented is very well suited to eliminate T-lymphocytes from great amounts of bone-marrow. The stem cells required to reconstitute the bone-marrow are enriched in this way. It can be completely performed in a closed system. Any contamination with germs is excluded. It can be reproduced well and learnt quickly. It takes 10 hours for two trained co-workers to process 1,500 ml of bone-marrow. The vitality of cells is very good (100%). Its suitability for transplantation has still to be checked.
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