A new method for measuring the free fraction of cyclosporin in plasma by equilibrium dialysis
Henricsson, S.
Journal of Pharmacy and Pharmacology 39(5): 384-385
1987
ISSN/ISBN: 0022-3573 PMID: 2886587 Document Number: 292457
The free fraction of cyclosporin in plasma has been measured by equilibrium dialysis in steel chambers. Equilibration time was 16 h. The intra-assay coefficient of variation was 7%. The free fraction remained constant in plasma samples frozen for up to 6 months, and was independent of the total concentration within the therapeutic range.
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