Morphological changes in the neuroendocrine system during experimental infection of animals with L-forms of group B Streptococcus
Khostikian, N.G.; Vartazarian, N.D.; Gorina, L.G.
Arkhiv Patologii 49(5): 64-70
1987
ISSN/ISBN: 0004-1955 PMID: 3304224 Document Number: 292181
White rats and mice were subjected to a single intraperitoneal inoculation with a stable L-form of Streptococcus B (strain 090). The hypothalamus, hypophysis and adrenal cortex of the animals were subsequently studied during one year. Progressive degenerative, inflammatory, necrotic and sclerotic changes found in the system hypothalamus-hypophysis-adrenals were due to the bacteria persistence in these organs leading to the disturbance of hormonal homeostasis and development of the system deficiency. There was also the tendency (in 6-12 months after the inoculation) to intensifying regeneration with partial recovery of the organs function.