Antibiotic prophylaxis with cefuroxime in arthroplasty of the knee
Johnson, D.P.
Journal of Bone and Joint Surgery. British Volume 69(5): 787-789
1987
ISSN/ISBN: 0301-620X PMID: 3316240 Document Number: 291048
A randomised prospective trial was undertaken of antibiotic prophylaxis given at various intervals before inflation of the tourniquet for arthroplasty of the knee. Cefuroxime assays of bone and subcutaneous fat from samples collected throughout the operation demonstrated that an interval of 10 minutes was necessary to obtain adequate prophylaxis. Improvement in the timing of antibiotic prophylaxis may result in a reduction in the incidence of infection.
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