Time dependence of the shedding of class i and Ii HLA antigens. Interrelation of the fluctuations of HLA-antigen shedding and 51Cr-labeled macromolecules
Musatov, M.I.; Kozhevnikov, V.S.; Konenkov, V.I.; Lozovoĭ, V.P.
Biulleten' Eksperimental'noi Biologii i Meditsiny 104(9): 327-329
1987
ISSN/ISBN: 0365-9615 PMID: 3663921 Document Number: 290769
Soluble HLA-A, -B and -DR antigens were determined every 10 min with a rate nephelometry method in supernatants of human mononuclear cells cultured for 3 hrs. The time-dependent oscillations in the quantity of soluble HLA antigens with ultradian (circadian) rhythm characteristics were found. Quantity oscillations of HLA-A antigens were synphase to HLA-B ones and antiphase to HLA-DR antigens. Amplitude characteristics were found to depend on the temperature and cytoskeleton activity.