Development of chronic renal cyclosporin-A toxicity
Klintmalm, G.
Nephrologie 8(3): 131-133
1987
ISSN/ISBN: 0250-4960 PMID: 3309701 Document Number: 290461
Treatment with cyclosporine in renal transplantation causes an increased incidence of interstitial fibrosis. The degree of interstitial fibrosis seems to be correlated with high cyclosporine consumption and episodes of acute CyA nephrotoxicity. The cause of acute CyA nephrotoxicity seems to be hemodynamic alterations. Whether this is the cause for the chronic nephrotoxicity has still not been shown.
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