Problems of uridine protection
Farkas, S.; Pfleiderer, W.
Nucleic Acids Symposium Series 18: 153-156
1987
ISSN/ISBN: 0261-3166 PMID: 3697115 Document Number: 288297
Various routes to synthesize 5'-O-dimethoxytrityl-O4-p-nitrophenylethyl- 2'-O-p-nitrophenylethylsulfonyluridine (7) as a useful intermediate in oligoribonucleotide synthesis have been investigated. The direct sulfonylation of 5'-dimethoxytrityl-O4-p-nitrophenylethyluridine (4) gave the best results despite the fact that 7 is formed in almost equal amounts with its 3'-NPES isomer (8) and the 2',3'-di-O-NPES derivative (6).