Urinary sodium & plasma renin activity following renal transplantation
Dash, S.C.; Malhotra, K.K.; Sharma, R.K.; Singh, K.R.; Siddiqui, H.H.; Dhawan, I.K.
Indian Journal of Medical Research 86: 221-225
1987
ISSN/ISBN: 0019-5340 PMID: 3323041 Document Number: 288182
In 20 normal adults (mean .+-. SD; serum creatinine 1.07 .+-. 0.23 mg/dl) eating ad lib, 24 h urinary sodium (UNaV) averaged 89.1mEq/day. By contrast, in 30 kidney transplant recipients with stable allograft function (serum creatinine 1.4 .+-. 0.34 mg/dl) eating ad lib, who were studied 1 month to 6 yr after renal transplant, the UNaV averaged 166.5 mEq/day. After 3 days of 'salt free' diet (sodium content about 25 mEq) mean UNaV in 20 normal adults fell to 23.65 mEq/day whereas in the RT group it averaged 120.03 mEq/day. In both the groups UNaV correlated to UcrV. Mean recumbent plasma renin activity (PRA) in control subjects before and after salt restriction was 1.3 and 4.63 ng/ml/h respectively whereas in RT group it was 2.08 and 2.31 ng/ml/h. Associated hypertension did not affect the changes in UNaV and PRA following sodium restriction. These data suggest that renal allograft recipients excrete more sodium and show poor PRA response to sodium depletion.