Lipodystrophy and dyslipidemia in human immunodeficiency virus-infected Thai patients receiving antiretroviral therapy
Chuapai, Y.; Kiertiburanakul, S.; Malathum, K.; Sungkanuparph, S.
Journal of the Medical Association of Thailand 90(3): 452-458
2007
ISSN/ISBN: 0125-2208 PMID: 17427520 Document Number: 2876
Background. Lipodystrophy and dyslipidemia are increasing problems in HN-infected patients receiving antiretroviral therapy (ART). Objective: Determine the prevalence and predicting factors for lipodystrophy and dyslipidemia in these patients.Material and Method. A cross-sectional study was performed on HN-infected patients receiving ART in January 2006. Clinical assessment for lipodystrophy and blood tests for lipid profile were obtained.Results: There were 56 patients with a mean age of 42.3 years and 71.4% were male. Lipodystrophy was detected in 66.1%. Baseline characteristics between patients with and without lipodystrophy were similar except for age, history of receiving d4T and undetectable HIV-RNA (p < 0.05). There was a high prevalence of dyslipidemia (53.6%). By logistic regression, undetectable HIV-RNA (odds ratio (OR) 6.4, p = 0.016) and receiving d4T (OR 7.4, p = 0.022) are predicting factors for lipodystrophy.Conclusion: Lipodystrophy and dyslipidemia in HN-infected Thai patients receiving ART are common. Clinical monitoring for these abnormalities during ART is highly recommended.
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