Pharmacokinetics of amikacin in the pediatric surgical field
Yura, J.; Hayashi, S.; Tsuruga, N.; Hashimoto, T.; Murata, Y.; Kamiya, Y.
Japanese Journal of Antibiotics 40(6): 1176-1182
1987
ISSN/ISBN: 0368-2781 PMID: 3669299 Document Number: 287215
Amikacin (AMK) was intravenously administered to pediatric surgical patients, and its pharmacokinetics were studied. The results obtained are summarized as follows: 1. The serum levels following administration were similar to those which had been reported by others. Urinary excretion was excellent. 2. The concentrations of AMK in pleural effusion of a postoperative premature baby was an effective level higher than MIC's to target organisms. 3. Bile levels of AMK were the highest soon after surgery on patients with biliary atresia, these declined as time passed. The high levels obtained were in the effective range where the levels were higher than MIC's against organisms isolated from bile of patients with biliary tract infections. Biliary excretions were good in cases with good hepato-enteric circulation. 4. Biliary and urinary excretion rates were well correlated.