Distribution of ceftriaxone in the tissues of the female genital system
Fraschini, F.; Zoncada, F.; Scaglione, F.; Radaelli, U.; Miraglia, M.; Valmaggi, P.; Falchi, M.; Ripamonti, L.
International Journal of Clinical Pharmacology Research 7(6): 499-502
1987
ISSN/ISBN: 0251-1649 PMID: 3440640 Document Number: 287054
Twenty-nine patients, hospitalized in order to undergo, gynaecological surgery involving organ removal, were treated with a single intramuscular administration of 1 g ceftriaxone before surgery. The tissue levels of the drug determined in the organs considered: uterus, ovary, fallopian tubes, vagina, proved to be comparable and to guarantee its satisfactory and uniform penetration into the tissues of the female genital system at a slowly decreasing rate. The high levels observed 12 h and 24 h after administration (2.24 .+-. 0.74 mcg/g; 3.58 .+-. 0.60 mcg/g; 0.70 .+-. 0.45 mcg/g; 1.20 .+-. 0.57 mcg/g in the ovaries and myometrium respectively) suggest a possible application of ceftriaxone in presurgical prophylaxis also in cases of female genital surgery.