Modulation of glycolysis by dibutyryl cyclic AMP in rat lung
Mahmood, T.; Singh, V.
Indian Journal of Biochemistry and Biophysics 23(2): 96-99
1986
ISSN/ISBN: 0301-1208 PMID: 3021612 Document Number: 285758
The rate of lactate production by rat lung slices and its modulation by DBcAMP have been studied to gain an insight into the mechanism of regulation of glycolysis in lung. DBcAMP was found to enhance the rate of lactate production by lung slices. To understand the basis for this stimulated glycolysis the steady-state levels of glycolytic intermediates in the lung under altered glycolytic flux were estimated. A crossover plot of glycolytic intermediates showed that the phosphofructokinase catalysed step was activated by DBcAMP.