Regeneration of changes induced in rabbit tracheal epithelium by a single oral dose of a mucolytic agent
Konrádová, V.; Vávrová, V.; Sulová, J.
Folia Morphologica 34(1): 52-58
1986
ISSN/ISBN: 0015-5640 PMID: 3699638 Document Number: 283209
The authors studied the process of the regeneration of changes induced by a single oral dose of 100 mg of carbocysteine in the airway epithelium. Rabbit tracheal epithelium was examined 20 and 60 min and 24, 48 and 72 h after administration of this substance. Carbocysteine did not have much of an effect on the ciliated cells, but it markedly stimulated and damaged the goblet ones. The percentage of degenerated goblet cells peaked in 60 min. 72 h after administration of the mucolytic agent 26% of the stimulated and 10% of degenerated goblet cells were left in the epithelium. The excessive amount of secretory material released all at once into the airway lumen due to the function of carbocysteine caused local disturbances of the mucus flow which were still pronounced 24 h after administration and had not disappeared completely by the end of the experimental period.