Retroviruses and the immune system
Smolle, J.; Kresbach, H.
Der Hautarzt; Zeitschrift für Dermatologie Venerologie und verwandte Gebiete 37(5): 242-244
1986
ISSN/ISBN: 0017-8470 PMID: 3015838 Document Number: 283016
Three examples are presented to illustrate the importance of retroviruses and associated oncogenes in neoplasms of the immune system. In adult T-cell leukemia/lymphoma the HTLV I-provirus is often integrated in the human genome on chromosome 8 adjacent to the c-myc protooncogene. Cytogenetic studies of Burkitt's lymphoma (translocation of a chromosome 8 fragment) and a case of mycosis fungoides (trisomy of chromosome 8) indicate that the same oncogene may possibly be activated not only by retroviruses, but also by chromosomal aberrations.