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Effect of leukocytic interferon on the functional state of bronchoalveolar phagocytes in lung diseases

Chernushenko, E.F.; Belianovskaia, T.I.; Kuznetsova, L.V.; Shpak, O.I.; Shatrov, V.A.

Terapevticheskii Arkhiv 58(4): 83-85

1986

ISSN/ISBN: 0040-3660
PMID: 3715762
Document Number: 282860
A study was made of the effect of leukocytic interferon on the phagocytic activity of alveolar macrophages and neutrophils in patients with chronic bronchitis, tuberculosis and sarcoidosis of the lungs. Cells isolated from the patients' bronchoalveolar washing off were used. It was concluded that short-term incubation of macrophages and neutrophils with interferon resulted in phagocytosis enhancement and increased intensity of metabolic processes in them. Interferon produced the most noticeable effect on cells with an initially reduced absorption capacity.

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