Kinetics of germ killing and damage to selected bacterial enzymes by thermal and chemical influences. I. Theoretical background of killing and enzyme inhibition kinetics
Senkpiel, K.; Machmerth, R.; Horn, H.
Zentralblatt für Bakteriologie Mikrobiologie und Hygiene. Serie B Umwelthygiene Krankenhaushygiene Arbeitshygiene Praventive Medizin 182(3): 267-278
1986
ISSN/ISBN: 0932-6073 PMID: 3092502 Document Number: 282524
Thermal and chemical influences on microorganisms and the kinetics of microbicidal processes are described in terms suitable to define the resistance of microbes to heat and disinfectants resp. sterilisants. Interactions between active substances (e.g. disinfectants) and enzymes are formulated in equations, and the parameters of kinetics of inactivating enzymes (e.g. Ki-values) are derived. They permit a gradual evaluation of efficacy of microbicidal agents irrespective of their concentration.