Effect of vitamin E on the oxidative metabolism of macrophages
Sharmanov, A.T.; Aĭdarkhanov, B.B.; Kurmangaliev, S.M.
Biulleten' Eksperimental'noi Biologii i Meditsiny 101(6): 723-725
1986
ISSN/ISBN: 0365-9615 PMID: 3730561 Document Number: 281926
The oxidative metabolism of macrophages in vitamin E deficiency was studied on Aug-Lac strain rats. Vitamin E deficiency was shown to enhance luminol-dependent chemiluminescence of macrophages stimulated by opsonized zymosan. There was also an increase in microviscosity of macrophage membrane lipid phase, that was estimated with a fluorescence probe. The incubation of macrophages with dl-.alpha.-tocopherol led to the inhibition of macrophage chemiluminescence. Superoxide dismutase, glutathione peroxidase and glutathione reductase activity was not affected by vitamin E deficiency.