An association between HLA DRI and lichen planus
Powell, F.C.; Rogers, R.S.; Dickson, E.R.; Moore, S.B.
British Journal of Dermatology 114(4): 473-478
1986
ISSN/ISBN: 0007-0963 PMID: 3485991 Document Number: 280738
Serological typing for HLA Class II antigens in 72 patients with lichen planus (LP) revealed a highly significant association with HLA DRI and MTI (DQWI). DRI was present in 80% of patients with generalized LP, 54% with localized LP, 56% of patients with drug-induced LP and in 31% of patients with mucosal LP, compared with 25% of normal controls. MTI (DQWI) was found in 83% of the LP group and 62% of the normal controls. These findings strongly suggest a genetic predisposition or susceptibility to the development of generalized LP and perhaps also to drug-induced LP.