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Recurrent deletion of the short arm of chromosome 3 in human renal cell carcinoma: shift of the c-raf 1 locus

Teyssier, J.R.; Henry, I.; Dozier, C.; Ferre, D.; Adnet, J.J.; Pluot, M.

Journal of the National Cancer Institute 77(6): 1187-1195

1986

ISSN/ISBN: 0027-8874
PMID: 3467112
Document Number: 280197
A cytogenetic study performed on 6 human renal cell carcinomas after short-term culture on extracellular matrix with serum-free medium showed aneuploidy without structural changes in 2 tumors and a rearrangement of the short arm of chromosome 3 in 4 tumors, including deletions and a translocation involving the 3p14 and 3p21 bands. Chromosomal in situ hybridization with a c-raf 1 probe demonstrated that in 2 renal cancers with del3(p14 or 21) the cellular oncogene had shifted from 3p25 to 3p14 as a result of an interstitial deletion.

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