Some aspects of clearance of mitoguazone in cancer patients and experimental cancer models
Dunzendorfer, U.; Balis, M.E.; Whitmore, W.F.
Arzneimittel-Forschung 36(3): 506-508
1986
ISSN/ISBN: 0004-4172 PMID: 3518731 Document Number: 279980
Mitoguazone (methylglyoxal-bis(guanyl-hydrazone), MGBG) was studied by its first-pass mechanism in both cancer patients and experimental cancer models. It appears from the study that 90% of MGBG is cleared from the plasma within minutes. 24-h recovery in the urine, however, did not exceed 16% so that 84% of the drug seems to be bound to subcellular compartments. Tissue levels of MGBG in the normal prostate ranged higher than in experimental prostate cancer type 3327 M/G, i.e. enhanced clearance from cancer tissues: polyamine biosynthetic enzymes ornithine decarboxylase as well as S-adenosylmethionine decarboxylase are contrarily affected by MGBG.