Familial nonspherocytic hemolytic anemia in poodles

Randolph, J.F.; Center, S.A.; Kallfelz, F.A.; Blue, J.T.; Dodds, W.J.; Harvey, J.W.; Paglia, D.E.; Walsh, K.M.; Shelly, S.M.; Randolph, J.F; Center, S.A; Kallfelz, F.A; Blue, J.T; Dodds, W.J; Harvey, J.W; Paglia, D.E; Walsh, K.M; Shelly, S.M

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Familial nonspherocytic hemolytic anemia in poodles

Randolph, J.F.; Center, S.A.; Kallfelz, F.A.; Blue, J.T.; Dodds, W.J.; Harvey, J.W.; Paglia, D.E.; Walsh, K.M.; Shelly, S.M.

American Journal of Veterinary Research 47(3): 687-695

1986

ISSN/ISBN: 0002-9645

PMID: 3963571

Document Number: 279511

Nonspherocytic hemolytic anemia, characterized by marked reticulocytosis, hepatosplenomegaly, hemosiderosis of reticuloendothelial organs and bone marrow myelofibrosis, and osteosclerosis, was diagnosed in 5 related Poodles. The unremitting anemia was clinically evident by 1 year of age, and was fatal as early as 3 years of age. Despite intense diagnostic endeavors including RBC fragility studies, RBC enzyme assays, and hemoglobin electrophoresis, the cause of this nonspherocytic hemolytic anemia remains to be determined.