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Morphology of the pancreas during intra-aortal administration of 5-fluorouracil

Titova, G.P.; Laptev, V.V.; Gaziev, R.M.

Biulleten' Eksperimental'noi Biologii i Meditsiny 101(5): 619-622

1986

ISSN/ISBN: 0365-9615
PMID: 3708151
Document Number: 278678
The results of the studies of morphological changes in the pancreas during intraaortal injections of various 5-fluorouracil doses to 44 dogs are reported. It was experimentally established that intraaortal injection of 10 mg 5-fluorouracil per kg of mass for 3 days caused the delay in albumin-synthesizing organella function, without damaging organellas as such. Administration of a cytostatic in a dose of 15 mg per kg of mass did not only cause a drastic decline in the synthesizing activity of cells in acinar parenchyma, but also induced intracellular lesions.

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