Sclerosing cholangitis, chronic pancreatitis and Sjögren's syndrome
Versapuech, J.M.; Labayle, D.; Grange, D.; Fischer, D.; Kemeny, F.; D'Hubert, E.
Annales de Medecine Interne 137(2): 147-151
1986
ISSN/ISBN: 0003-410X PMID: 3717820 Document Number: 278325
A 63 year old man was followed up for chronic pancreatitis. After 2 years, he developed features of primary sclerosing cholangitis associated with Sjögren's syndrome. A review of the literature revealed 38 previous cases of chronic pancreatitis associated with sclerosing cholangitis; a sicca complex was also demonstrated in 3 of these cases. Chronic pancreatitis is mostly asymptomatic and the diagnosis is usually made at laparotomy or postmortem. Retrograde pancreatograms are abnormal in 15-75 p. 100 of patients with primary sclerosing cholangitis. The relationship between the two diseases is not a coincidence. On the other hand, the significance of the association with the Sjögren's syndrome remains controversial.