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Animal experiment studies of the modification of pregnancy by heterologous antibodies to placental antigens

Canzler, E.; Böhme, G.; Morenz, J.; Röse, I.

Zentralblatt für Gynakologie 108(3): 167-174

1986

ISSN/ISBN: 0044-4197
PMID: 3754371
Document Number: 276938
Pregnancy impairment in mice with abortion and fetal resorption was caused by rabbit antibodies to total mitochondrial, mitochondrial membrane and microsomal fractions of mouse placentas injected intraperitoneally at 12-14 days of gestation. Antibodies to cytosol and soluble mitochondrial constituents were ineffective. According to the marker distribution in the biologically active and inactive fractions membrane-bound antigens are thought to be responsible for the abortigenic effect.

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