Reactivity of the cardiovascular system and of the pressor neurohumoral systems in hypertension patients
Shkhvatsabaia, I.K.; Ustinova, S.E.; De Quattro, V.; Oshchepkova, E.V.; Parfenova, E.V.
Kardiologiia 26(1): 44-48
1986
ISSN/ISBN: 0022-9040 PMID: 3951134 Document Number: 276587
Correlations between sympathoadrenal, renin-angiotensin and cardiovascular (BP and heart rate) response to psychoemotional and physical stress and antebrachial skin vascular response to noradrenaline were examined in patients with essential hypertension. Four groups of patients were identified on the basis of the magnitude of variation in the examined parameters. The progress of the disease over the past two years was assessed in all patients. The prognosis was particularly unfavorable in the "hyperreactive" group which showed a set of distinctive features: increased vascular response to noradrenaline, a greater BP rise in response to stress, greater sympathoadrenal activation, increased neuroticism, as well as significantly older age of the patients and greater severity and duration of the disease. No intergroup differences in plasma renin activity could be demonstrated. Possible use of vascular response to noradrenaline, and BP and plasma catecholamine variation in response to psychoemotional stress as criteria for the assessment of the severity and outcome of essential hypertension is discussed.