1H-NMR spectroscopy of the cell membranes of thymus lymphocytes in AKR mice
Iushmanov, V.E.; Erokhin, V.N.; Dronova, L.M.; Belich, E.I.; Kurushin, E.A.
Biofizika 31(5): 829-832
1986
ISSN/ISBN: 0006-3029 PMID: 3778958 Document Number: 275643
360 MHz 1H NMR was used to monitor the changes of AKR mice thymus lymphocytes in cases of spontaneous and transplantable leukemia and vincristine administration. A comparison of relative signal intensities of methyl and methylene fatty acid chains protons and phosphatidylcholine headgroups protons enables to monitor leukemia development and vincristine effect. Spin-lattice relaxation curves of the same protons of leukemic thymi lymphocytes are well fitted by biexponential functions, bringing evidence for two regions with different lipid mobility.