Recurrent thromboembolic events in heterozygous protein C deficiency
Bulvik, S.; Kaufman, N.; Flatau, E.
Harefuah 110(11): 553-554
1986
ISSN/ISBN: 0017-7768 PMID: 3770578 Document Number: 275581
Protein C is a vitamin K-dependent plasma glycoprotein that potently inhibits coagulation by inactivating factors V and VIII and facilitating fibrinolysis in vivo. Subnormal levels of protein C are associated with recurrent thromboembolism. We describe a 50-year-old man with heterozygous protein C deficiency manifested by recurrent episodes of superficial and deep vein thrombosis, pulmonary embolism and cerebrovascular accidents. The diagnosis of protein C deficiency should be considered whenever a patient, especially if young, presents with recurrent thrombotic phenomena in the absence of an underlying systemic disease. Findings that increase the suspicion of protein C deficiency include unusual sites of thromboses, family history of thromboembolic phenomena and increased resistance to conventional anti-coagulant therapy. Early diagnosis and treatment may decrease the mutilating and potentially fatal complications of this disease.