Hyperthyroidism following hypothyroidism
McDermott, M.T.; Kidd, G.S.; Dodson, L.E.; Hofeldt, F.D.
American Journal of the Medical Sciences 291(3): 194-198
1986
ISSN/ISBN: 0002-9629 PMID: 3006488 Document Number: 274972
Two patients are presented who developed autonomous thyrotoxicosis following a diagnosis of primary hypothyroidism. In one of these patients, antibodies to the TSH receptor were typical of Graves' disease when measured as thyrotropin binding inhibitor immunoglobulins (TBII) and as human thyroid adenylate cyclase stimulating (HTACS) activity, while a needle biopsy of the thyroid gland was consistent with lymphocytic thyroiditis. Twenty-one other reported cases of this unusual sequence found in the literature are reviewed. This occurrence is more common than is generally appreciated.