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Aldosterone content and renin activity in the plasma of hypothyroidism patients before and during treatment with thyroid preparations

Egart, F.M.; Atamanova, T.M.; Nazarov, A.N.

Problemy Endokrinologii 32(1): 35-38

1986

ISSN/ISBN: 0375-9660
PMID: 3513156
Document Number: 274027
A study was made of aldosterone (A) level and plasma renin activity (PRA) in 47 patients with hypothyrosis of various degree of severity prior to and during therapy with thyroid drugs. A normal basal A level in the blood plasma was noted, in some patients it was raised or lowered. The following tendency was revealed during therapy with thyroid drugs: in patients with lowered A and PRA levels a rise of these levels was noted during treatment, in raised levels a significant drop was noted. Normal A and PRA basal levels (in most of the patients) showed in the process of treatment diverse tendencies: toward a decrease in the A level and a rise of the PRA level within normal range. The results obtained indicated independent effect of thyroid hormones on A and PRA synthesis. In case of low level of endogenous thyroid hormones as well as exposure to exogenous thyroid hormones changes in the A level were not directly controlled by PRA.

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