Blood to brain transfer of carbon tetrachloride and lipoperoxidation in rat brain
Watanabe, A.; Shiota, T.; Takei, N.; Fujiwara, M.; Nagashima, H.
Research Communications in Chemical Pathology and Pharmacology 51(1): 137-140
1986
ISSN/ISBN: 0034-5164 PMID: 3952367 Document Number: 273897
[14C]-Carbon tetrachloride (CCl4) entered extensively into the liver and, to the small extent, into the brain 3 hr following the intragastric administration of the hepatotoxic dose. Although thiobarbituric acid (TBA) in the liver homogenates increased 12 hr after CCl4 administration, the brain showed little TBA values probably due to very low levels of chytochromes P-450 and b5 in the brain. These results suggest that CCl4 have no direct toxic effect upon the brain.