Cutaneous malignant melanoma in women and the role of oral contraceptives

Gefeller, O.; Hassan, K.; Wille, L.

British Journal of Dermatology 138(1): 122-124

1998


ISSN/ISBN: 0007-0963
PMID: 9536234
DOI: 10.1046/j.1365-2133.1998.02037.x
Document Number: 273309
The role of oral contraceptives (OC) in the aetiology of cutaneous malignant melanoma (CMM) has been controversially discussed over the last two decades. In an extensive literature search we identified 18 case-control studies, published between 1977 and 1996, offering information on this relationship. Using a meta-analytical approach we combined the study-specific risk estimates and derived a summary odds ratio of 0.95 (95% confidence interval: 0.87-1.04). Based on the data of 3796 cases and 9442 controls, we thus found no evidence for an aetiological role of OC use in the development of CMM.

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